Flexeril Side Effects: Frequent Symptoms and Signs

Overdose can manifest with any of the adverse side effects mentioned previously in this article. The United States Food and Drug Association(FDA) categorizes Flexeril as pregnancy risk category B. There are several cyclobenzaprine warnings and precautions with use. These syndromes can produce life-threatening complications. Therefore patients should be cautioned against the following cyclobenzaprine warnings.

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Those with relatively less severe addiction issues who wish to remain active in their personal and professional lives during treatment typically prefer outpatient rehab programs. Patients can continue to work, go to school, and fulfill other responsibilities while still making a commitment to their recovery. A 2011, a double-blind randomized placebo-controlled study published by The Journal of Rheumatology found that the drug may also be useful in treating those with fibromyalgia sleep better. A 2016 drug used to deliver cyclobenzaprine into the body of fibromyalgia patients was recently halted during trials.

Find Flexeril Addiction Treatment Programs

Multiple drug ingestion (including alcohol) is common in deliberate cyclobenzaprine overdose. As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. Signs and symptoms of toxicity may develop rapidly after cyclobenzaprine overdose; therefore, hospital monitoring is required as soon as possible. The acute oral LD50 of FLEXERIL is approximately 338 and 425 mg/kg in mice and rats, respectively. Prescription use of Cyclobenzaprine subjected to the supervision of a licensed doctor is most commonly linked with a non-emergent, tolerable adverse reaction. These reactions develop in ≥3% of the patients and consist of xerostomia, drowsiness, and dizziness all connected to the anticholinergic effects of cyclobenzaprine drug class.

• Your doctor will write the number of refills authorized on your prescription.
• Check with your doctor before taking any of the above while you are using this medicine.
• As such, problems related to Cyclobenzaprine side effects are commonly encountered and are of medical importance.
• Ask your doctor when to start or stop taking this medication.
• The overall incidence of adverse reactions among patients in the surveillance program was less than the incidence in the controlled clinical studies.

Cyclobenzaprine is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries. Cyclobenzaprine is in a class of medications called skeletal muscle relaxants. It works by acting in the brain and nervous system to allow the muscles to relax. The plasma concentration of cyclobenzaprine is increased in the elderly (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Elderly).

What happens if I miss a dose?

Physostigmine is not recommended except to treat life-threatening symptoms that have been unresponsive to other therapies, and then only in close consultation with a poison control center. In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at FDA-1088 or at /medwatch.

This weight gain is thought to be attributed to a period of physical inactivity caused by muscle relaxant use. Information on whether long-term use of Flexeril has any impact on weight gain is unknown. As mentioned above, the biochemical relationship to cyclical antidepressants makes Cyclobenzaprine have central depressing effects. These effects can be markedly accentuated if Flexeril use is supplemented with related CNS depressing agents such as alcohol or barbiturates.

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Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation. Hyperpyretic crisis seizures, and deaths have occurred in patients receiving cyclobenzaprine (or structurally similar tricyclic antidepressants) concomitantly with MAO inhibitor drugs. Although rare, deaths may occur from overdosage with FLEXERIL.

Pain Amplification Syndromes

Central nervous system depression, seizures, heart attack, and even death can occur. Cyclobenzaprine is a centrally acting skeletal muscle relaxant structurally related to tricyclic antidepressants. Cyclobenzaprine is a tricyclic amine salt that works in the central nervous system (CNS) as a depressant that reduces muscle hyperactivity.

Eight double-blind controlled clinical studies were performed in 642 patients comparing FLEXERIL 10 mg, diazepam, and placebo. Muscle spasm, local pain and tenderness, limitation of motion, and restriction in activities of daily living were evaluated. In three of these studies there was a significantly greater improvement with FLEXERIL than with diazepam, while in the other studies the improvement following both treatments was comparable. Cyclobenzaprine caused slight to moderate increase in heart rate in animals. For most patients, the recommended dose of FLEXERIL is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day.

Flexeril is used to relieve muscle spasm when the spasm is due to local problems, that is, in the muscle itself and not in the nerves controlling the muscles. Flexeril seems to accomplish its beneficial effect through a complex mechanism does flexeril affect the heart within the nervous system, probably in the brainstem. Severe CNS depression may result in significantly slowed breathing, over sedation, coma, and death.3 If you are unable to stop abusing one or more substance, it’s time to seek help.